Co-evolution of strain design methods based on flux balance and elementary mode analysis
نویسندگان
چکیده
منابع مشابه
Co-evolution of strain design methods based on flux balance and elementary mode analysis
More than a decade ago, the first genome-scale metabolic models for two of the most relevant microbes for biotechnology applications, Escherichia coli and Saccaromyces cerevisiae, were published. Shortly after followed the publication of OptKnock, the first strain design method using bilevel optimization to couple cellular growth with the production of a target product. This initiated the devel...
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ژورنال
عنوان ژورنال: Metabolic Engineering Communications
سال: 2015
ISSN: 2214-0301
DOI: 10.1016/j.meteno.2015.04.001